Cashew allergy anal Patch#

A real-time PCR method targeting a multicopy sequence from mitochondrial DNA has proven suitable for sensitive detection and even quantification of the allergenic ingredient peanut at the level of 5 mg/kg (Ladenburger et al. In routine analysis, predominantly protocols based on real-time polymerase chain reaction (PCR) and immunological methods have been used (EFSA 2014). The values are taking into account the published eliciting doses (Remington et al 2020). These action values serve as internal minimal thresholds by food control authorities and support laboratories in the decision-making process, whether further inspections at the production facility may be neglected or not (Waiblinger and Schulze 2018). The official food control laboratories in Germany are working with an internal action value of 1 mg protein/kg (derived from peanut or tree nut) or 5 mg/kg whole peanut or tree nut, respectively. An important factor for setting thresholds for food allergens is the availability of standardized methods for detection and quantification with sufficient sensitivity to detect even low amounts of allergenic components, if relevant. The implementation of legal threshold values is currently under discussion. In the case of positive findings, a quantification of the respective allergens or allergenic ingredients may be crucial for risk assessment, allergen management, and surveillance (The Allergen Bureau Waiblinger and Schulze 2018). Within the European Union, labelling is mandatory for food ingredients containing-amongst others-peanut, hazelnut, walnut and cashew (Regulation 2011/1169/EC). To ensure the availability of information about the presence of relevant allergens in food, labelling provisions have been set in many countries. However, the list of foods which account for most of the severe disease courses is rather short, namely peanut, tree nuts, fish, shellfish, egg, milk, wheat, soy, and seeds (Sicherer and Sampson 2018), with the first two being among the most frequent triggers for food allergies in Europe (Nwaru et al. The occurrence of food allergies can be observed more frequently among children than adults. Mass spectrometry of the cashew shell extract suggested the presence of cardol, one of the allergens in cashew shell oil.There is extensive data suggesting that food allergies are already ubiquitous (up to 10% of people affected) with sharp increases mainly in the last 2–3 decades (Sicherer and Sampson 2018).

The three who were not sensitive to poison ivy had no reaction to cashew extract. All nine who reacted to the cashew extract also reacted to poison ivy urushiol.

Cashew allergy anal Patch#

Absence of cashew nut shells from two thirds of the bags probably accounted for the lack of correlation between patch testing and illness. Patch testing did not predict illness since positive tests to both materials occurred in those who had been ill as well as in those who had been well.

Nineteen volunteers (eleven ill and eight well) were patch-tested with 2.5 micrograms of poison ivy urushiol and an acetone extract of cashew nut shells. Three had blistering of the mouth and four had rectal itching. The patients had a very pruritic, erythematous, maculopapular eruption that was accentuated in the flexural areas of the body. Between April 4 and May 10, 1982, fifty-four individuals developed a poison ivy-like dermatitis 1 to 8 days after eating imported cashew nuts.